Oct262023

Challenging Clinical Perspectives in Type 2 Diabetes with Tirzepatide, a First-in-Class Twincretin

Recent Publications

Tirzepatide is a first-in-class GIP/GLP-1 receptor agonist (‘twincretin’)—a single molecule that acts as an agonist at both glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors. In the SURPASS clinical trial program in type 2 diabetes mellitus (T2D), tirzepatide was associated with unprecedented reductions in HbA1c, clinically significant weight loss and other metabolic benefits,…

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Oct262023

Early Type 2 Diabetes Treatment Intensification with Glucagon-Like Peptide-1 Receptor Agonists in Primary Care: An Australian Perspective on Guidelines and the Global Evidence

Recent Publications

Early and intensive management of type 2 diabetes has been shown to delay disease progression, reduce the risk of cardiorenal complications and prolong time to treatment failure. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are being increasingly recognized for their potential in early disease management, with recent guideline updates recommending second-line use of this injectable drug class…

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Oct262023

Sodium-Glucose Cotransporter 2 Inhibitor Effects on Heart Failure Hospitalization and Cardiac Function: Systematic Review

Recent Publications

This paper, co-authored by Associate Professor Roy Rasalam (Principal Investigator at AusTrials Sunshine in Melbourne), systematically reviews randomized controlled trials assessing effects of sodium–glucose cotransporter 2 inhibitors (SGLT2is) on hospitalization for heart failure (HHF) and cardiac structure/function and explore randomized controlled trial (RCT)-derived evidence for SGLT2i efficacy mechanisms in heart failure (HF). This review found…

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Sep62023

AusTrials Celebrates the Grand Opening of New Clinical Research Site – AusTrials Sunshine

Latest News

Tuesday 22nd August 2023    AusTrials welcomed the Mayor of Brimbank, Councillor Bruce Lancashire and around 60 guests to the official opening of our newest site located in the Sunshine Private Hospital, St Albans in Melbourne’s west.     The state-of-the-art facility, named AusTrials Sunshine, will mark the expansion of AusTrials from Queensland into Victoria and…

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